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This uncertainty can be represented formally with wide 95 percent confidence intervals, Androxy, ranging from 15 to 65 percent, say. In other words, we are very confident that the true response rate of MX320 lies somewhere between 15 percent and 65 percent. Since there is typically much more evidence about the standard treatment, there will also be less uncertainty around this estimate (e. We can thus establish that there ought to be a state of clinical equipoise: since the confidence intervals of our average effect estimates for these two treatments overlap, there is legitimate scientific uncertainty about which is better. Furthermore, since the interval for MX320 does not fall below the interval for standard treatment, then both are consistent with competent medical care. If we assume the RCT is using Fluoxymesterone equal allocation ratio, then there was a 50 percent chance that Charlie would get assigned to the MX320 arm. Malone observes that he is not responding to therapy, it is now a slightly better bet that he is in the control arm. But this Androxy still far from certain. Halotestin tablets may be a late responder, or the new drug may just not be effective for him.

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